Clonal expansion analysis
WebFeb 24, 2024 · The underlying processes associated with clonal expansion are best studied by detecting somatic mutations or other acquired alterations, such as copy number variations and DNA methylation,... WebOct 21, 2024 · Clonal diversity is a consequence of cancer cell evolution driven by Darwinian selection. Precise characterization of clonal architecture is essential to understand the evolutionary history of...
Clonal expansion analysis
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WebSep 5, 2015 · Clones are the fundamental building blocks of immune repertoires. The number of different clones relates to the diversity of the repertoire, whereas their size …
WebSep 5, 2015 · Clones, or collections of genetically similar cells (as defined by similarities in their antibody heavy chain, light chain or a combination of both), emerge at these … WebFeb 3, 2024 · Clonal expansion is defined as the proliferative expansion of a single progenitor cell. This process has been observed in physiological and pathological settings. Recently, Jaiswal and Ebert 1 noted that it is likely that cells in all mitotically active tissues are capable of clonal expansion.
Web2 days ago · Using this dataset, we tested whether the T allele was associated with the expansion rate of clonal haematopoiesis clones. We defined clonal expansion as the … WebFeb 23, 2024 · Phylogenetic analysis revealed clonal distribution of Tn 916 -like ICEs in SDSE isolates. Our findings suggest that Tn 916 -like ICEs contributed to the emergence and recent increase of multidrug-resistant SDSE bacteremia in this region of Japan.
WebJul 1, 2001 · As Dippel et al remind us, PB T-cell clonal expansions occur in multiple clinical settings. 1-1 For example, peripheral blood expansion of CD8 + clones have been described in healthy individuals, as well as in patients with rheumatoid arthritis, and have been shown to be remarkably stable over time (up to 4 years). 1-2 They increased with …
WebOct 2, 2024 · This observation demonstrates that drastic clonal expansions have occurred in some individual MNU tissues. One possible explanation for this observation is that … darkmoon faire prize ticket wotlkWebSep 12, 2024 · In the current study, we evaluated the clonal expansion and TCR repertoire at the nucleotide level in 108 PTCLs (40 AITLs, 35 ALCLs, 17 PTCL-NOS, 15 NKCLs, and one γδ-TCL). bishop julius mcallister bioWebOct 1, 2024 · Immune fitness in health and disease depends notably on the diversity of cellular repertoires. Single-cell sequencing is fostering the understanding of clonal diversity of T-cell repertoires combined to transcriptomic profiling. Structural TCR clustering is a promising tool for epitome mapping of immune repertoires. dark moon characters webtoonWeb2 days ago · For analysis of incident disease, ... Xie, M. et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat. Med. 20, 1472–1478 (2014). bishop justice schoolWebApr 15, 2015 · To explore the clonal status of mutations in established cancer genes, we first identified all nonsilent mutations that occurred in known cancer driver genes based on the recent pan-cancer analysis by Lawrence et al. ( 1) combined with the manually curated COSMIC gene census ( 23) (table S1). darkmoon faire buffWebAug 25, 2014 · To examine the possibility that the clonal expansions within the naïve compartment represented a contamination with effector T cells masquerading as naïve T cells, we analyzed all TCRB sequences that were found at more than 0.01% frequency in the naïve T-cell population for their representation in the memory population. bishop junior high school bishop texasWebApr 8, 2024 · Calamagrostis epigejos (L.) Roth is one of the most expansive clonal grass species. Despite many publications about its biology, the expansive mechanism of C. epigejos is relatively unknown. Therefore, the aim of this study was to determine: I. the dependency between Calamagrostis epigejos ramet density, habitat properties, and the … bishop junior school