WebBeatriz Mercado, Grace Rosner, and Elora Greiner were selected for NSF GRFP awards and Samantha Liu has earned an Honorable Mention. Beatriz Mercado is a second year MCB … WebNon-essential proteins for viral replication affect host cell metabolism, while the function of the UL43 protein of herpes simplex virus 1 (HSV-1) is not clear. Herein, we performed a comprehensive microarray analysis of HUVEC cells infected with HSV-1 and its UL43-deficient mutant and found significant variation in genes associated with cellular energy …
Understanding the host-microbe interactions using metabolic modeling …
WebMetastasis, the major cause of death in cancer patients, is a multistep process involving metabolic and epigenetic rewiring in cancer cells (intrinsic) and the host tissue parenchyma (extrinsic), both at the primary and secondary sites of cancer spread [1,2]. From the days of the ‘seed and soil’ hypothesis of cancer metastasis, some studies have demonstrated … WebMar 5, 2024 · Results of a published study showed that the replication of the influenza virus depends on host cellular metabolism such that metabolites including nucleic acids, proteins, glycoproteins, and lipids are crucially required for the life cycle of the influenza virus [ 7 ]. fzzpvx
Metabolic reprogramming as a feast for virus replication
WebViruses actively reprogram host cell metabolism to establish optimal environment for their replication and spread. They stimulate the uptake of extracellular nutrients and predominantly modulate glucose, glutamine, and fatty acid metabolism to support anabolic metabolic pathways. Some viruses activate the process of aerobic glycolysis, divert ... WebMany successful intracellular bacterial pathogens exploit nutrients and metabolites available in host cells to benefit colonization and replication. Despite significant advances in other … WebApr 10, 2024 · Here we show that host Sirtuin 2 (SIRT2) inhibition by AGK2 significantly enhances the BCG vaccine efficacy during primary infection and TB recurrence through enhanced stem cell memory (TSCM) responses. SIRT2 inhibition modulated the proteome landscape of CD4+ T cells affecting pathways involved in cellular metabolism and T cell … fzzqk-gbk1-0