Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family. It is known to play an important role in the maturation of T cell populations through activation of antigen-presenting cells. TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and different types of … Visa mer TSLP production has been observed in various species, including humans and mice. In humans TSLP is encoded by the TSLP gene. Alternative splicing of this gene results in two transcript variants. Visa mer It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of myeloid (CD11c ) dendritic cells. TSLP … Visa mer The TSLP signaling axis is an attractive therapeutic target. Amgen's Tezepelumab, a monoclonal antibody which blocks TSLP, is currently approved … Visa mer • Overview of all the structural information available in the PDB for UniProt: Q969D9 (Thymic stromal lymphopoietin) at the PDBe-KB. Visa mer TSLP expression is linked to many disease states including asthma, inflammatory arthritis, atopic dermatitis, eczema, eosinophilic esophagitis and other allergic states. The factors … Visa mer • Ziegler SF, Liu YJ (July 2006). "Thymic stromal lymphopoietin in normal and pathogenic T cell development and function". Nature Immunology. 7 (7): 709–14. doi:10.1038/ni1360. PMID 16785889. S2CID 26635282. • Liu YJ (August 2007). Visa mer Webb8 apr. 2024 · Topical emollient reduces serum thymic stromal lymphopoietin (TSLP) and IgE levels in atopic dermatitis (AD) mice. The serum TSLP, IL-4 and total IgE levels were measured by ELISA. Data are shown as mean ± SEM. N …
Hypoxia-inducible factor prolyl hydroxylase inhibitors suppressed ...
Webb1 aug. 2011 · Thymic stromal lymphopoietin (TSLP) is a type 1 cytokine that contributes to lymphopoiesis and the development of asthma and atopic dermatitis. TSLP acts on multiple lineages, including dendritic cells (DCs), T cells, NKT cells, eosinophils, and mast cells, mediating proliferation and survival and linking innate and adaptive immune … Webb1 mars 2012 · Thymic Stromal Lymphopoietin (TSLP) is an IL-2 cytokine family member secreted by various non-immune cells, such as epithelial cells, smooth muscle cells, fibroblasts, and epidermal... landscaping jobs part time
Thymic Stromal Lymphopoietin - an overview
Webb7 feb. 2024 · Introduction. In this study, we aimed to compare the immunophenotype of tumor cells in children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) harboring rearrangements of the CRLF2 gene with that in children without such aberrations with a specific focus on the surface expression of the related protein thymic stromal … WebbThymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine that induces type 2 immune response through dendritic cell activation. Therefore, TSLP inhibitors may serve as novel antiallergic drugs. Hypoxia-inducible factor (HIF) activation in the epithelia contributes to several homeostatic phenomena, ... hemisphere\\u0027s ex